News of medicine

Here you will find new scientific findings on metabolic and vascular disease.

Women's Health : "the pill " and breast cancer

When more than ten years ago, the data of the large " Women's Health Study" ( WHI ) was published by the United States , the understanding of hormone therapy changed fundamentally in the menopause. During decades earlier therapies were treated menopausal symptoms in women early and in all stages of life with estrogen - progesterone, the WHI study showed a completely different picture :

The impression was that the hormone therapy is associated with the development of cardiovascular diseases and especially but also with the emergence of breast cancer. A new analysis of the WHI study now shows that the hormone regulation has changed in the age group 50 to 69 years for women basic: 12.7% of those involved in the study, women hormones were enacted in the year 2001 , as was the number in 2004 only 4.9% . The frequency of breast cancer was in this period from 296.3 to 268 related back to one hundred thousand women. Looking at the data more closely, despite the decline in hormone regulation , a significant increase in the incidence of breast cancer in the age group of 50 to 69 years can be observed. It is now clear that the hormone itself does not cause breast cancer , but also accelerates the growth of estrogen -dependent breast tumors.

What does this mean for everyday practice?

The menopausal symptoms are usually caused by estrogen deficiency. The faster dries up the production of estrogen , the greater the likely complaints such as hot flushes , sweating , anxiety and depressive moods . The hot flashes do not harm , but are part of growing older woman to do so. On the contrary, they are an expression of good health , as recent studies show is the stronger the hot flashes are , the lower the risk - sometimes up to 50 % - of developing breast cancer (biomarkers , epidemiology and prevention , 2011).
One must always be clearly stated : the menopause or menopause is a natural event in a woman's life and are not at increased risk for cardiovascular disease, diabetes mellitus or other diseases.
An adapted to the individual needs of women estrogens may reduce the discomfort or even eliminate . By administering estrogen gel or patches you can perform a needs-based estrogen therapy. It is important that you should avoid the use of estrogen / progesterone tablets more . The background is that tablets are metabolised by the liver and thus degradation products arising from these estrogens , which are responsible under certain circumstances for development of carcinoma . This is avoided with the use of gels or patches. Sometimes in women a " pill therapy " Yet is required. This should be used only for a certain period and the woman doctor should regularly the breast or the ovaries and the uterus are examined.

Is there an alternative to this " hormonal " ?

Studies have shown that the fitness and the body weight of the woman are the crucial factors, such as women get through menopause . Studies clearly show that regular endurance training menopausal symptoms significantly reduced. Weight gain during menopause is always present : about seven percent of their starting weight , take the women . Often they observe a slight increase in the waist. The lack of estrogen causes the hip fat increases. This redistribution of body fat also changes your metabolism. The stronger the abdominal fat (waist increases) , the worse glucose and lipid / cholesterol metabolism.
Numerous studies on the effectiveness of homeopathic remedies or phytotherapeutics that contain " natural" estrogens have not shown any clear results . In practices, they are always like applied from experience. If discomfort , however, can not be reduced , alternative therapy should be considered

Genomics - proteomics - Metabolomics : "EVA " and then " ADAM " - resist premature "aging"

Diseases develop slowly : only change cells their programs (genes) , signals are formed to manufacture new substances (proteins = proteins) , which then start like in a chain reaction of other programs in other cells : constantly run these programs at the end of " health "or" disease " are .

Cardiovascular diseases are the result of disturbances in cholesterol , fat and sugar metabolism. Usually take decades - so it was thought until just 10 years - until they cause discomfort , ie Organ systems in their function affect (eg, heart attack , stroke ) . In contrast to laboratory values ​​, such as cholesterol, lipids or inflammatory markers , which reflect only a snapshot of the health of a people , make new analysis methods , such as ultrasound of the vessels with wall thickness measurement , pulse wave analysis and measurement of the elasticity of the vessels , a detailed statement about the "aging" human . Prof. Peter Nilsson , University of Lund, defined in 2009 (Hypertension 2009,54:3 ) the value of this diagnostic method for detection of early vascular aging ( "Early Vascular Aging ", " EVA" syndrome). With the help of this method is the first time the dynamics , ie the speed detected with the state of the vessels to deteriorate ( atherosclerosis ) or even improved. The latter process is set by the influence of risk markers of atherosclerosis in transition . Nilsson describes this approach as " ADAM ": " Aggressive Decrease of Atherosclerosis Modifiers " .

Since 8 years, these methods are described in studies at the Institute for Metabolic Research - used Frankfurt as well as in the metabolic center of the Rhine- Main. Besides the University of Mainz, Department of Cardiology and Angiology, the metabolic center of the Rhine -Main is the only facility in the south- west of Germany , which employs this method of analysis . In conjunction with new metabolic markers an individual risk profile is created , which can be assessed in the severity of the disease ( metabolomics ): an "Age of sugar " is not equal to "Age of sugar " - depending on how ausschauen the vessels , how resilient they are, the different is the severity.

Together with Prof. Nilsson , Dr. Konrad and other European metabolism and vascular health professionals a European body was launched in Geneva in May 2011, which is intended to promote this diagnosis at the international level . Background : usually rich in the early phase of the "EVA" syndrome from lifestyle changes to slow the rapid aging of the vessels. In November 2011, a consensus paper was presented at the " Zurich Conference" together , to be published worldwide in medical journals as a recommendation to doctors for early diagnosis of metabolic and vascular disease.